Stereoselective Synthesis and Functionalization of Acetylenic Boronic Esters

Key Points

• The research explores the stereoselective synthesis and functionalization of acetylenic boronic esters for creating complex organic structures.
• Conducted hydrozirconation of homopropargyl boronic esters to achieve selective functionalization.
• Utilized metal-halogen exchange to produce reactive vinyl iodides for further reactions.
• Employed Negishi couplings and Heck reactions to synthesize polyketide-like structures.
• Successfully generated functionalized alkenes through selective transformations.
• Demonstrated the preservation of boronic ester functionality during the synthesis process.
• Produced polyketide-like structures relevant for natural product synthesis.