What question did this study set out to answer?

The aim is to review recent advancements in quercetin-based delivery systems and their implications in therapeutics.

April 22, 2026Open Access

Quercetin-Based Advanced Delivery Systems – From Multimodal Nano-theranostics to Microneedles: a Recent Update on Their Preclinical Studies

MBMaya BeenaVellore Institute of Technology University AUAnjaneyulu UdduttulaVellore Institute of Technology University APArunkumar PalaniappanSynergy University Dubai

Puntos clave

The aim is to review recent advancements in quercetin-based delivery systems and their implications in therapeutics.
Systematic analysis of recent preclinical studies on quercetin delivery systems.
Examination of formulation strategies such as nanoencapsulation and microneedles.
Discussion on challenges like bioavailability and targeted delivery.
Innovative delivery systems have improved quercetin's stability and bioavailability.
Theranostic platforms using quercetin may enhance treatment precision and effectiveness.
Key challenges remain in scalability and achieving controlled release.

Resumen

Abstract: Quercetin is a naturally derived flavonoid that has received growing attention for its wide range of pharmacological activities such as strong anticancer, antimicrobial, anti-inflammatory, and antioxidant effects. Its multiple functions and natural bioactivity make it an appealing therapeutic candidate. However, the clinical use of quercetin is still limited by issues like poor water solubility, low bioavailability, fast metabolism, and difficulties in achieving targeted delivery. Recent research has aimed to overcome these challenges through innovative formulation strategies like nanoencapsulation, polymeric carriers, 3D printing, microneedle scaffolds and surface modification. These approaches improve stability, boost bioavailability, and allow for targeted therapeutic effects. Traditional theranostic systems that use nanoparticles, quantum dots, or linked biomolecules have enhanced precision medicine by merging diagnostic imaging methods, such as MRI, PET, and fluorescence, with treatment options like targeted drug delivery and photothermal therapy. Yet, these systems face issues related to biocompatibility, cost, biodegradability, and targeting precision. Platforms based on quercetin are emerging as a promising alternative to tackle these problems. Despite their potential, this area is largely uncharted, and, to our knowledge, no thorough review has focused on quercetin’s role in multifunctional theranostic systems. This review offers a systematic look at the design strategies, biomedical uses, and potential for quercetin-based theranostics. We discuss key challenges, such as achieving controlled/stimuli-responsive delivery, validation in higher animal studies, scale-up and to emphasize future directions for evolving quercetin-based platforms as next-generation nano-theranostics. Keywords: quercetin, theranostics, microneedle, 3D bioprinted, pharmaceuticals, multifunctional

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