italicJiannao Bushen Oral Liquid/italic （健脑补肾口服液） ameliorates cognitive function in Alzheimers disease mice by suppressing oxidative stress via the cGAS/STING pathway

Key Points

• The aim is to investigate how Jiannao Bushen oral liquid enhances cognitive function in Alzheimer’s disease mice by suppressing oxidative stress via the cGAS/STING pathway.
• Randomly assigned male SAMP8 mice to model, donepezil, and JNBSL groups, with anti-aging SAMR1 as control.
• Administered treatments for 90 days and evaluated cognitive behavior using the Morris water maze and open field test.
• Conducted immunofluorescence and Western blot analyses to assess Aβ levels and cGAS/STING expression.
• JNBSL treatment significantly improved cognitive function compared to the model group (P<0.05).
• Reduced Aβ deposition and improved mitochondrial morphology were observed in the JNBSL group.
• cGAS/STING expression decreased significantly, along with increased GSH-Px, SOD, and CAT activities.