Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Key Points

• The aim is to assess how REM sleep behavior disorder (iRBD) relates to early symptoms of synucleinopathy.
• Examined clinical features of individuals with REM sleep behavior disorder (iRBD)
• Identified biomarkers associated with synucleinopathy
• Assessed multi-domain clinical impairments
• iRBD is linked to significant clinical impairments across multiple domains
• Biomarker-defined synucleinopathy is prevalent in affected individuals
• Early detection may facilitate better management of potential neurodegenerative diseases