TITLE: Exo-Systems Medicine - A Biophysical framework for Vata Dosha disruption in Microgravity (0g) EXTENDED ABSTRACT Prolonged exposure to microgravity (0g) environments induces a complex, systemic physiological derangement. While conventional aerospace medicine often addresses these dysfunctions as isolated phenomena (e.g., bone demineralization, cephalad fluid shifts, or muscular atrophy), this paper introduces Exo-Systems Medicine. This novel paradigm of translational systems biology aims to integrate classical Ayurvedic ontologies with modern biophysical principles to identify a unifying cause for such multi-systemic imbalances. Methodology and framework The framework formalizes the concept of Vata Dosha Displacement not as a metaphysical construct, but as a quantifiable dysregulation of movement, transport, and signaling processes at the molecular, cellular, and systemic levels. By synthesizing the Cellular Tensegrity model (Ingber), the Exclusion Zone (EZ) Water theory (Pollack), and PNEI (Psycho-Neuro-Endocrine-Immunology) physiology, the study maps the perturbations induced by gravitational unloading. Results and Discussion It is hypothesized that the central mechanistic "missing link" would reside in the decoupling of circadian oscillators from the mechanosensing functions of primary cilia. In a 0g environment, the loss of gravitational loading could alter the tensegrity of the cytoskeleton, thereby degrading the coherence of intra- and extracellular EZ water. This process might lead to a significant increase in metabolic entropy (MIME - Microgravity-Induced Metabolic Entropy) and a subsequent breakdown in bioelectrical signaling. The framework further proposes a precise anatomical mapping of the Srotas (Ayurvedic physiological channels) onto their modern correlates: the glymphatic system, interstitial fluid flow, and lymphatic microvasculature. Within this model, Vata "displacement" would be defined as a reversal of flows (Pratiloma), which could hinder the clearance of metabolic waste (Ama) and the efficient distribution of signaling molecules. Conclusions and Implications The Exo-Systems Medicine framework would provide a predictive model for managing human resilience in space. Furthermore, it could offer a high-resolution lens for understanding terrestrial pathologies associated with accelerated aging and neurodegeneration. We suggest that future countermeasure strategies should focus on optimizing the bio-terrain through mechanobiological resonance, electromagnetic coherence, and integrated chrono-pharmacology. SCIENTIFIC & LEGAL DISCLAIMER 1. Nature of the Framework: this document, titled "EXO-SYSTEMS MEDICINE: A Biophysical Framework for Vata Dosha Disruption in Microgravity," represents a theoretical and translational study in the field of Systems Biology and Bio-Systems Engineering. It is intended for research, academic, and heuristic purposes only. The correlations between Ayurvedic ontologies and modern biophysics (e.g., Vata Displacement and Mechanotransduction) are proposed as a novel "translational symmetry" to guide future empirical investigations. 2. No Medical Advice: the contents of this white paper, including proposed countermeasure strategies and metabolic priming protocols, do not constitute medical advice, diagnosis, or treatment. They are theoretical models based on systems biology simulations and literature review. No clinical action should be taken based on this framework without direct supervision from qualified medical professionals and aerospace health authorities. 3. Intellectual Property & Originality: the concepts of "Vata Displacement" in 0g, "Hydrogenomics applied to Exo-medicine," and the specific mapping of "Srotas-Glymphatic-Interstitial Axis" are original intellectual contributions of the author (Valentina Luongo). Any reproduction, citation, or use of these specific translational models must be appropriately credited via the provided Zenodo DOI. 4. Experimental Limitations: while grounded in verified biophysical data (tensegrity models, EZ water theory, circadian genetics), the systemic synthesis presented herein is "Speculative-Translational." Its predictive accuracy in extra-terrestrial environments is subject to further validation through peer-reviewed clinical trials and aerospace physiological monitoring. 5. Liability: the author shall not be held liable for any direct or indirect consequences arising from the application of the theories or information contained in this document.
V. Luongo (Thu,) studied this question.