Harnessing the Synergy of Green Solvents and Iron Nanoparticles for Pyrazole Derivative Synthesis: Recent Advancements and Future Perspectives

ABSTRACT Over the past decades, green synthesis has been introduced for the generation of diverse array of valuable organic heterocycles through safer, more effective, and environmentally sustainable manner. Pyrazole derivatives have maintained an indispensable role among heterocycles in recent decades due to their extensive applications in daily life. The synthesis of pyrazole derivatives is much sought after and is a significant focus of research within the scientific community. In this context, Fe NPs serve as a catalytic system that efficiently facilitates the organic reactions to get pyrazole derivatives. Green solvents garner significant interest from researchers due to their non‐toxic properties. The integration of green solvent and Fe NPs as a sustainable system aligns with the principles of green chemistry. This green catalytic system has effectively produced pyrazole derivatives for numerous decades. The current review strongly focused on the synergistic role of green solvent and Fe NPs in the development of diversified pyrazole scaffolds. This is the first report that demonstrates the green solvent‐solvated and Fe NPs‐catalyzed approaches towards the synthesis of pyrazole based molecular architectures.