Methamphetamine Use Among Adult Patients Presenting With Acute Coronary Syndrome: A Single-Center Retrospective Cohort Study.

BACKGROUND: Methamphetamine-associated acute coronary syndrome (ACS) has not been previously well studied. METHODS: This retrospective, single-center study included all patients aged 18 to 65 years who presented with ACS and underwent coronary angiography from 2012 to 2022. Patients who used cocaine or had other non-type 1 myocardial infarction were excluded. Cox proportional hazard regression and survival analyses were performed to assess all-cause mortality. RESULTS: <0.001). CONCLUSIONS: ACS related to methamphetamine use is primarily observed in younger men with adverse social determinants of health and is strongly associated with mortality. Strategies for prevention unique to this population are warranted.