Bail-out DES implantation after suboptimal DCB angioplasty was safe, with no increased risk of 1-year target lesion failure compared to a 7.0% performance goal for upfront DES (P=0.048).
Observational
Yes
Does bail-out DES implantation after suboptimal DCB angioplasty prevent target lesion failure at 1 year compared to a performance goal for an upfront DES-only strategy in patients undergoing percutaneous coronary intervention?
Bail-out DES implantation after suboptimal DCB angioplasty appears safe, with 1-year target lesion failure rates comparable to an upfront DES-only strategy.
p-value: p==0.048
BACKGROUND: Drug-coated balloons (DCBs) are increasingly adopted in percutaneous coronary intervention. Bail-out drug-eluting stent (DES) implantation due to suboptimal immediate results after DCB angioplasty is not infrequent, and the clinical outcomes of percutaneous coronary intervention with DCB angioplasty followed by bail-out DES implantation remain unexplored. The aim of this study was to evaluate the safety of bail-out DES implantation following DCB angioplasty in percutaneous coronary intervention. METHODS: The BAILOUT registry included consecutive patients undergoing bail-out DES implantation after DCB angioplasty at 17 European centers between 2011 and 2024. The primary end point was target lesion failure (TLF) at 1 year, defined as the composite of target lesion revascularization, target vessel myocardial infarction, and cardiac death. The TLF rate was compared with a performance goal of 7.0% for an upfront DES-only strategy, derived from a meta-analysis of contemporary randomized controlled trials. RESULTS: =0.048). CONCLUSIONS: In cases of suboptimal angiographic results after DCB angioplasty, bail-out DES implantation is safe, with no increased risk of TLF at 1 year compared with the expected performance goal for an upfront DES-only strategy.
Gitto et al. (Thu,) conducted a observational in Suboptimal immediate results after drug-coated balloon angioplasty. Bail-out drug-eluting stent (DES) implantation vs. Performance goal of 7.0% for an upfront DES-only strategy was evaluated on Target lesion failure (TLF) at 1 year (composite of target lesion revascularization, target vessel myocardial infarction, and cardiac death) (p==0.048). Bail-out DES implantation after suboptimal DCB angioplasty was safe, with no increased risk of 1-year target lesion failure compared to a 7.0% performance goal for upfront DES (P=0.048).