This work presents Structural Medicine v3. 5, extending the control-theoretic framework of neurodegenerative dynamics to a physically interpretable level. Previous versions (v3. 0–v3. 4) introduced an adaptive control formulationU (t) = A (t) sin (ω (t) t + φ (t) ), but did not specify its physical realization. In this study, five candidate intervention modalities (tACS, tDCS, TMS, pharmacological agents, and cognitive training) are systematically evaluated against the structural requirements of the control formulation. We identify transcranial alternating current stimulation (tACS) as the modality providing the most direct structural correspondence, with explicit mapping to amplitude A (t), frequency ω (t), and phase φ (t). Importantly, this correspondence is defined at the level of structural form rather than strict dynamical equivalence across temporal scales. The framework yields three jointly falsifiable predictions: Phase-specific suppression of instability (anti-phase control) Non-monotonic amplitude response with optimal current I* Existence of a controllable window Wcontrol determining responder classification We explicitly identify the multi-scale coupling problem—linking fast neural oscillations (~40 Hz) and slow structural dynamics (~0. 05 yr⁻¹) —as the central unresolved issue. This work establishes a physically interpretable candidate realization of the Structural Medicine control framework while preserving falsifiability and theoretical transparency.
Koji Okino (Tue,) studied this question.