Abstract Number: Esoc2026a2448 Poor Long-Term Functional Outcome in Patients With Acute Ischemic Stroke Due to Anterior Circulation Large Vessel Occlusion Treated With Mechanical Thrombectomy With Successful Reperfusion

Abstract Background and aims The results of earlier research showed that the degree of reperfusion does not necessarily correlate with good functional recovery. Our work aimed to determine the predictors of poor long-term functional outcome in patients treated with mechanical thrombectomy (MT) in whom successful reperfusion was achieved. Methods The study included 127 patients with acute ischemic stroke who underwent MT. Numerous sociodemographic and clinical characteristics of the patients were collected, as well as technical information related to the procedure itself. Successful reperfusion was defined as an mTICI score ≥2b. Poor functional outcome was defined as a modified Rankin score (mRS) of 3-6 at the end of the 1-year follow-up period. Results Successful reperfusion was achieved in 111 (87.4%) patients treated with MT, of which 53 (47.7%) patients had a poor functional outcome (mRS 3-6) at one-year follow-up. Multivariate Cox regression analysis showed that independent predictors of one-year poor functional outcome after successful reperfusion were higher premorbid mRS score (HR 1.66; 95% CI (1.02-2.70), p=0.041), higher initial NIHSS score (HR 1.06; 95% CI (1.01-1.11), p=0.010), presence of atrial fibrillation (HR 3.07; 95% CI (1.66-5.65), p=0.000) and high Charlson comorbidity index (HR 1.34; 95% CI (1.05-1.72), p=0.019). Conclusions A higher degree of premorbid functional disability, more severe neurological deficit at initial presentation, the presence of atrial fibrillation and a high Charlson comorbidity index are independent predictors of long-term poor functional outcome in patients with AIS due to anterior circulation LVO treated with MT in whom successful reperfusion was achieved. Conflict of interest The authors declare that they have no conflict of interests.