Abstract : Introduction: Human Immunodeficiency Virus (HIV) remains a global health problem, especially in high-risk groups of men who have sex with men (MSM). Pre-Exposure Prophylaxis (PrEP) is an effective HIV prevention strategy, but its success is highly dependent on the level of adherence to use. Objective: This study aims to analyse the effect of education and motivation on non-adherence to PrEP use in men who have sex with men in Kemiling District, Bandar Lampung, Indonesia. Methods: This study used an observational analytical design with a cross-sectional approach conducted in January–February 2026 with a sample of 64 respondents selected using proportional random sampling. Data were collected through a structured questionnaire, with non-adherence measured using the MMAS-8, and analysed using the Chi-Square test. Results: The results showed that education (p=0.016; OR=4.427; 95% CI: 1.441–13.602) and motivation (p=0.003; OR=6.240; 95% CI: 1.923–20.248) significantly influenced non-adherence to PrEP use. Respondents with higher education and good motivation tended to be more adherent compared to respondents with lower education and less motivation. Conclusion: It can be concluded that education and motivation are important factors influencing non-adherence to PrEP use. Therefore, interventions that emphasize increasing health literacy and strengthening motivation through ongoing education and counselling are needed to improve PrEP adherence in the MSM population.
Hertarsih et al. (Wed,) studied this question.