Metastatic Malignant Melanoma Mimicking Pancreatic Adenocarcinoma

ABSTRACT Malignant melanoma is an aggressive cutaneous malignancy with a high propensity for lymphatic and distant metastasis. While it commonly spreads to lymph nodes, lungs, brain, liver, and the gastrointestinal tract, pancreatic involvement is generally rare, occurring in less than 1% of cases. We report a case of metastatic melanoma initially misdiagnosed as pancreatic adenocarcinoma. This case underscores the importance of maintaining a broad differential, obtaining tissue diagnosis, and using immunohistochemistry to avoid diagnostic anchoring and ensure accurate identification of metastatic melanoma.