Objectives/Goals: Rush University developed human-centered design studios to help translation research teams overcome recruitment and retention barriers in clinical trials. We describe the adaptation process and lessons learned when implementing these studios at The University of Chicago (UChicago). Methods/Study Population: UChicago studios followed the core Rush design, including study presentation, process mapping, partner identification, insight framing, and idea generation, but were adapted to local context and resources. The main adaptation transitioned the role of studio facilitator from a faculty human-centered design expert to trained research coordinators. This process included structured training and adaptation of workflows within the institutional context. Regular cross-institutional meetings provided a forum to debrief challenges and implement needed adjustments. Evaluation data included attendance records, post-session surveys, and regular debriefs to assess fidelity and adaptation. Results/Anticipated Results: In 2025, six 1-hour studios were held at UChicago, averaging eight participants per session (range 6–10; n=50). Participants included faculty and research, administrative, and community engagement staff. Feedback surveys (n=14) yielded a Net Promoter Score of 85 (12 promoters, 2 passives, and 0 detractors). Among respondents, 71% found sessions useful, 50% were first-time attendees, and 57% attended primarily to help research teams overcome recruitment barriers. Participants described the studios as valuable for generating concrete solutions and fostering cross-departmental connections. Key challenges included sustaining attendance, expanding presenter recruitment, and engaging more faculty. Discussion/Significance of Impact: Replication of design studios at UChicago demonstrates that the model can be sustained through trained non-faculty facilitators. Key lessons include the importance of faculty mentorship, facilitator training, consistent coordination, and cross-institutional learning to strengthen implementation.
Leung et al. (Wed,) studied this question.