Antihypertensive medication adherence definitions and study designs show wide variability across North American and European populations in an ongoing systematic review of 119 studies.
Systematic Review
This systematic review will clarify key predictors of antihypertensive medication non-adherence to guide future adherence-improving strategies and population-specific hypertension management policies.
Objectives/Goals: This study aims to identify socioeconomic, clinical, and behavioral risk factors of non-adherence for adults with hypertension and evaluate implications for future treatment strategies. Methods/Study Population: We will conduct a systematic review following PRISMA guidelines. Eligible studies are peer-reviewed RCTs and observational designs assessing factors associated with antihypertensive medication adherence among adults (≥18 years) with hypertension living in North America or Europe. Studies must report adherence as the primary outcome. Studies will be excluded if they are not peer-reviewed, original research articles, published in a non-English language, reviews or meta-analyses, or studies of an intervention aimed at improving adherence. Abstract and title screening, full paper review, and data extraction will be performed in Covidence by two reviewers with conflicts resolved by consensus. Results/Anticipated Results: A total of 5660 records were imported for screening after duplicate removal. Following title and abstract screening, 4990 studies were excluded as irrelevant, leaving 670 records for full-text review. Of 611 full texts reviewed, 491 studies were excluded and 39 are pending conflict resolution. Currently, 119 studies are marked for data extraction. Data to be extracted will include socioeconomic, demographic, clinical, and behavioral determinants of antihypertensive medication adherence. Quality assurance will involve dual independent extraction. Preliminary trends suggest wide variability in study designs and adherence definitions across North American and European populations. Discussion/Significance of Impact: Findings will clarify key predictors of antihypertensive medication non-adherence and highlight gaps in evidence. Results will guide future adherence-improving strategies and inform design of simplified regimens, digital tools, and population-specific hypertension management policies.
Parsa et al. (Wed,) conducted a systematic review in Hypertension. Antihypertensive medication was evaluated on Factors associated with antihypertensive medication adherence. Antihypertensive medication adherence definitions and study designs show wide variability across North American and European populations in an ongoing systematic review of 119 studies.