Early Detection of Pulmonary Mucormycosis Using Microbial Cell-Free DNA Sequencing of Bronchoalveolar Lavage Fluid in Neutropenic Hosts: A Report of Two Cases

Key Points

• This research aims to explore the efficacy of microbial cell-free DNA sequencing for early detection of pulmonary mucormycosis in neutropenic hosts.
• Case reports of 2 immunocompromised patients with suspected invasive mucormycosis.
• Utilization of microbial cell-free DNA sequencing of bronchoalveolar lavage fluid for diagnosis.
• Monitoring the impact of early diagnosis on treatment outcomes and surgical interventions.
• Microbial cell-free DNA sequencing led to significantly quicker diagnosis in both cases.
• Early intervention included surgical procedures and antimicrobial treatments, improving patient outcomes.