Sensitization of Common Allergens and Cosensitization Patterns Among Children in Guangzhou, China

Background Pediatric allergic diseases vary by region. Subtropical sensitization profiles and their clinical implications remain poorly defined. Method In this retrospective study, specific immunoglobulin E (sIgE) levels to eight common allergens were obtained from children assessed for allergy‐associated symptoms in our department between November 1, 2017, and April 29, 2020. Result Of the 1755 patients, Dermatophagoides pteronyssinus (Der p) (46.5%) and Dermatophagoides farinae (Der f; 45.7%) showed high rates of sensitization. More than 80% of shrimp‐sensitized children exhibited cross‐reactivity to Der p, Der f, and cockroach. After adjusting for potential confounding variables, inhalant sensitization (OR = 2.131; 95% confidence interval CI: 1.506–3.015; p < 0.001) and polysensitization (OR = 1.480; 95% CI: 1.023–2.141; p = 0.038) were both associated with an increased risk of allergic airway disease. Conclusion Our study identified the “mite–shrimp” sensitization cluster in subtropical children and establishes inhalant sensitization and polysensitization as the key risk factor in allergic respiratory diseases. These findings support the development of region‐specific and component‐resolved diagnostic strategies for pediatric allergy prevention.