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May 13, 2026

The Comparison of Contrast Sensitivity After Keratorefractive Lenticule Extraction Between the VisuMax 800 and 500 Systems

JHJ HuZhejiang Chinese Medical University ZWZhanying WangQinghai University YBYongle BaoAcademy of Medical Sciences

Key Points

To compare contrast sensitivity after keratorefractive lenticule extraction using VisuMax 800 and 500 systems.
Participants aged 18 to 46 years received keratorefractive lenticule extraction.
Contrast sensitivity was measured using quantitative CSF tests at 1, 3, and 6 months postoperatively.
Differential and influencing factor analyses on qCSF parameters were conducted.
VisuMax 800 showed better qCSF at 1 month postoperatively (P < .05).
No significant differences in qCSF between groups at 3 and 6 months (P > .05).
Significant correlations between refraction types and contrast sensitivity in both groups (P < .05).

Abstract

Purpose: To compare the contrast sensitivity (CS) after keratorefractive lenticule extraction (KLEx) between the VisuMax 800 and VisuMax 500 systems (Carl Zeiss Meditec AG). Methods: Participants aged 18 to 46 years were recruited between November 2024 and April 2025. Visual and refractive outcomes were assessed and CS function (CSF) was measured using the quantitative CSF (qCSF) test at 1, 3, and 6 months postoperatively. The differential analysis and influencing factor analysis of qCSF parameters between the two systems were conducted. Results: In the VisuMax 800 group, qCSF parameters at 1 month postoperatively were better than those in the VisuMax 500 group ( P .05). In the VisuMax 500 group, preoperative and postoperative cylindrical refraction were significantly correlated with CS (6 cycles per degree cpd) and CS (12 cpd) ( P < .05). In the VisuMax 800 group, preoperative and postoperative spherical refraction (SR) and postoperative SR was were significantly correlated with CS (6 cpd) and CS (12 cpd) ( P < .05). CS (12 cpd) in the VisuMax 500 group and CS (6 cpd) in the VisuMax 800 group were correlated with the optical zone ( P < .05). Conclusions: The VisuMax 800 system demonstrates a slight advantage in the early recovery of visual function following KLEx, particularly excelling in CS at medium and high spatial frequencies, and its outcomes converge with those of the VisuMax 500 system at postoperative 3 and 6 months.

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