What question did this study set out to answer?

The aim is to assess clinical determinants and predictive biomarkers for chemotherapy response in advanced non-small cell lung cancer.

May 14, 2026

Clinical determinants and biomarkers for predicting chemotherapeutic response in advanced non-small cell lung cancer: a single-center retrospective study

Key Points

The aim is to assess clinical determinants and predictive biomarkers for chemotherapy response in advanced non-small cell lung cancer.
Evaluated 146 patients with advanced NSCLC based on RECIST version 1.1 criteria.
Analyzed pre-chemotherapy inflammatory indexes, tumor markers, and nutritional indicators.
Utilized the ECOG performance status and disease staging to assess their impacts.
ECOG score ≥2, stage IV disease, multiple metastases, and liver metastases negatively affected chemotherapy response.
Baseline NLR, PLR, CEA, CYFRA21-1, ALB, and HGB demonstrated predictive utility.
A favorable response to chemotherapy correlated with improved survival rates. Significant p < 0.001.

Abstract

OBJECTIVE: To evaluate clinical determinants and predictive biomarkers for response to platinum-based doublet chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). METHODS: = 146) according to RECIST version 1.1. Clinical characteristics, pre-chemotherapy inflammatory indexes neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), tumor markers carcinoembryonic antigen (CEA), cytokeratin 19 fragment antigen 21-1 (CYFRA21-1), and nutritional indicators albumin (ALB), hemoglobin (HGB) were analyzed. RESULTS: < 0.001). CONCLUSION: ECOG score ≥2, stage IV disease, multiple metastases, and liver metastases negatively impact chemotherapeutic response, whereas treatment continuity is protective. Baseline NLR, PLR, CEA, CYFRA21-1, ALB, and HGB show predictive utility. A favorable chemotherapeutic response is associated with significantly enhanced survival.

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Cite This Study

Zhang et al. (Tue,) studied this question.

synapsesocial.com/papers/6a056714a550a87e60a1f182 https://doi.org/https://doi.org/10.1080/1750743x.2026.2665977

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