Adults with type 1 diabetes exhibited reduced fluid cognition (p=0.01) and elevated crystallized cognition (p=0.0001) compared to normative data, without consistent links to metabolic risk factors.
Observational
Are metabolic factors and microvascular complications associated with brain health in adults with type 1 diabetes?
51 adults with type 1 diabetes
Normative data
Cognitive function (fluid and crystallized cognition) and brain health (assessed via MRI in a subset)surrogate
Adults with type 1 diabetes may exhibit subtle cognitive changes compared to normative data, though these changes are not consistently driven by traditional metabolic or microvascular risk factors.
We examined relationships between metabolic factors, microvascular complications, and brain health in adults with type 1 diabetes. Fifty-one adults were assessed for metabolic risk factors, microvascular complications, and cognitive function, with a subset completing brain MRI. Compared to normative data, participants showed reduced fluid cognition (p = 0.01) but elevated crystallized cognition (p = 0.0001). Microvascular complications and metabolic risk factors (including obesity, diabetes duration, and HbA1c) were not consistently linked to brain health outcomes. These exploratory findings suggest subtle cognitive changes in adults with type 1 diabetes, though larger longitudinal studies are needed to clarify how metabolic and microvascular factors influence brain health.
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Jihyun Park
Emily J. Koubek
Richard Beare
Annals of Clinical and Translational Neurology
University of Michigan
Michigan State University
Oregon Health & Science University
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Park et al. (Tue,) conducted a observational in Type 1 diabetes (n=51). Type 1 diabetes and associated metabolic/microvascular risk factors vs. Normative data was evaluated on Cognitive function (fluid and crystallized cognition) and brain health outcomes (p=0.01). Adults with type 1 diabetes exhibited reduced fluid cognition (p=0.01) and elevated crystallized cognition (p=0.0001) compared to normative data, without consistent links to metabolic risk factors.
www.synapsesocial.com/papers/6a056751a550a87e60a1f5d3 — DOI: https://doi.org/10.1002/acn3.70428