Perimenopausal women had higher age-adjusted odds of a poor overall Life's Essential 8 score compared with premenopausal women (OR 1.92; 95% CI 1.13-3.26).
Cross-Sectional
Does perimenopausal status worsen Life's Essential 8 cardiovascular health scores compared to premenopausal status in women without prior cardiovascular disease?
Perimenopause is associated with significantly higher odds of poor cardiovascular health metrics, specifically lipid and glucose scores, compared to premenopause.
Effect estimate: OR 1.92 (95% CI 1.13-3.26)
p-value: p=<0.001
BACKGROUND: This study assessed cardiovascular health in women using the American Heart Association's Life's Essential 8 (LE8) score, and compared cardiovascular health across premenopausal, perimenopausal, and postmenopausal stages. METHODS: Data from the National Health and Nutritional Examination Survey cycles 2007 to 2020 were used and included women aged 18 to 80 years who were not pregnant or breastfeeding and without prior cardiovascular disease. Menopausal status was classified as pre-, peri-, or postmenopausal. LE8 scores were calculated as the continuous mean of 8 component scores and also categorized as poor, intermediate, or ideal. National Health and Nutritional Examination Survey analytical guidelines were followed. Adjusted linear regression models were used to assess temporal trends. RESULTS: <0.001). In comparison with premenopausal women, perimenopausal women were found to have higher age-adjusted odds of categorical poor overall LE8 (adjusted odds ratio, 1.92 95% CI, 1.13-3.26), poor lipid score (adjusted odds ratio, 1.76 95% CI, 1.12-2.76), and poor glucose score (adjusted odds ratio, 1.83 95% CI, 1.06-3.17). CONCLUSIONS: A decline in crude overall LE8 scores was observed from pre- to postmenopause, but age-adjusted categorical analyses showed the highest odds of poor LE8 scores and poor lipid and glucose scores in perimenopause.
““This demonstrates that we really should be acting sooner. As soon as someone starts to enter the perimenopause phase, we really should be much more aggressive from a primary prevention standpoint instead of waiting until they’ve already gone through menopause.””
Nayak et al. (Wed,) conducted a cross-sectional in Cardiovascular health. Perimenopause vs. Premenopause was evaluated on Categorical poor overall Life's Essential 8 (LE8) score (OR 1.92, 95% CI 1.13-3.26, p=<0.001). Perimenopausal women had higher age-adjusted odds of a poor overall Life's Essential 8 score compared with premenopausal women (OR 1.92; 95% CI 1.13-3.26).