Twelve recommendations for PFO-associated stroke management were developed, emphasizing universal screening for cryptogenic stroke patients aged ≤60 years and TCD as first-line screening.
What are the consensus recommendations for the diagnosis and management of patent foramen ovale for stroke prevention in Australia and New Zealand?
This consensus statement provides standardized recommendations for PFO management in Australia and New Zealand, emphasizing TCD screening, PASCAL classification, and multidisciplinary heart-brain teams.
INTRODUCTION: Patent foramen ovale (PFO) is implicated in 25%-50% of cryptogenic strokes in patients aged 60 years with embolic stroke of undetermined source, absent vascular risk factors and excluded atrial fibrillation. For diagnostic investigations: Transcranial Doppler (TCD) bubble study as preferred first-line screening where available, with transthoracic echocardiography as an alternative when TCD is unavailable and transoesophageal echocardiography for confirmation before closure consideration. For treatment decisions: Incorporation of the PFO-Associated Stroke Causal Likelihood (PASCAL) classification system rather than the Risk of Paradoxical Embolism (RoPE) score alone, consideration of TCD grading results for risk stratification and mandatory multidisciplinary heart-brain team evaluation for all closure decisions. CHANGES IN MANAGEMENT AS A RESULT OF THIS CONSENSUS STATEMENT: These recommendations will standardise practice through enhanced TCD service provision, structured heart-brain team development and evidence-based patient selection using the PASCAL classification. The emphasis on TCD as first-line screening represents a departure from traditional transthoracic echocardiography-based approaches. Implementation will improve patient outcomes through appropriate intervention in suitable candidates while avoiding unnecessary procedures in those unlikely to benefit, thereby promoting equitable access to optimal PFO management across Australia and New Zealand.
Chambers et al. (Fri,) conducted a review in Patent foramen ovale (PFO) and cryptogenic stroke. Consensus recommendations for PFO management was evaluated. Twelve recommendations for PFO-associated stroke management were developed, emphasizing universal screening for cryptogenic stroke patients aged ≤60 years and TCD as first-line screening.