The KA Operational Universality Framework -- established theoretically in Papers 1-2, benchmarked on calibrated simulations in Paper 3, and analysed via renormalisation group methods in Paper 4 -- has remained without real-data validation. This paper closes that gap. Real-data validation (OP3, OP4). We extract FKA and R (t) from three real-world datasets: (1) MIMIC-III intensive care records (n=1, 151 sepsis episodes) ; (2) USGS Advanced National Seismic System catalogue (Parkfield segment, 1987-2004, n=87 foreshock sequences) ; (3) MODIS NDVI time series for five Sahel sites (n=5 collapse events). FKA achieves AUC 0. 79+/-0. 06, 0. 83+/-0. 07, and 0. 81+/-0. 09 respectively, outperforming CSD variance (AUC 0. 68-0. 74) and lag-1 autocorrelation (AUC 0. 64-0. 71). The R (t) discrimination criterion is confirmed in all domains (AUC 0. 88-0. 92). Universal T*=1. 0 transfers with deltaAUC <=0. 03. Coupling dynamics (OP6). The endogenous coupling equation dC/dt = F (S, Sigma, M, E) proposed in Paper 2 is derived from a stochastic Volterra integral representation of the SDE covariance evolution. In the Markov limit, the closed-form equation predicts exponential runaway near the critical manifold: C (t) ~ C (t0) *exp (-lambda* (t-t0) ). Confirmed in 77. 2% of MIMIC-III pre-transition windows (R²=0. 71+/-0. 18).
Karimov et al. (Fri,) studied this question.