What question did this study set out to answer?

This research aims to evaluate the brain age gap across multiple disorders to understand patterns of accelerated brain aging.

May 18, 2026Open Access

Aging beyond diagnosis: the MRI brain age gap across disorders

HMHamad Yahia Abu MhannaThe University of Queensland LOLena OestreichThe University of Queensland RVRajat VashisthaThe University of Queensland

Key Points

This research aims to evaluate the brain age gap across multiple disorders to understand patterns of accelerated brain aging.
Analyzed 65 MRI-based studies covering conditions like AD, MCI, MS, PD, SCZ, stroke, and BD.
Calculated brain age gap and standardized mean differences (Hedges’ g) between patient and control groups.
Conducted subgroup analyses and meta-regressions to assess influences of age and disorder characteristics.
BAG was significantly elevated across all disorders, with the largest effects in MS (mean adjusted BAG = 7.81 years; g = 0.89) and AD (5.57 years; g = 0.66).
Moderate increases in BAG observed in SCZ (4.40 years; g = 0.42) and MCI (3.77 years; g = 0.43).
BAG largely independent of chronological age in neurodegenerative disorders but increased with age in SCZ.

Abstract

Abstract The brain age gap (BAG), the difference between magnetic resonance imaging–predicted brain age and chronological age, is a proposed marker of neurobiological aging, yet its transdiagnostic significance remains uncertain. This meta-analysis evaluated BAG in Alzheimer’s disease (AD), mild cognitive impairment (MCI), multiple sclerosis (MS), Parkinson’s disease (PD), schizophrenia (SCZ), stroke, and bipolar disorder (BD) to determine shared and disorder-specific patterns of accelerated brain aging. Sixty-five MRI-based studies were included. For each cohort, BAG was extracted or calculated, and standardized mean differences (Hedges’ g ) were computed between patient and healthy control groups using random-effects models. Subgroup analyses and meta-regressions were conducted to assess the influence of age and disorder characteristics. Publication bias and heterogeneity were evaluated using Egger’s test, I 2 statistics, and trim-and-fill procedures. BAG was significantly elevated across all disorders. The largest effects were observed in MS (mean adjusted BAG = 7.81 years; g = 0.89) and AD (5.57 years; g = 0.66). Meta-analyses of adequately powered disorders showed moderate elevations in SCZ (4.40 years; g = 0.42) and MCI (3.77 years; g = 0.43), while PD showed smaller but significant acceleration (3.52 years; g = 0.37). Descriptively, stroke (2 cohorts; mean adjusted BAG = 4.63 years) and BD (1 cohort; mean adjusted BAG = 4.84 years) also showed elevated BAG, though insufficient study numbers precluded formal meta-analysis for these disorders. BAG was largely independent of chronological age in neurodegenerative disorders but increased with age in SCZ. These findings support BAG as a transdiagnostic indicator of apparent accelerated brain aging in conditions where the meta-analytic evidence base is robust (AD, MCI, MS, PD, SCZ), while stroke and BD remain preliminary owing to limited cohort numbers. The magnitude of BAG varies substantially across conditions, and very high between-study heterogeneity ( I 2 > 90% in most disorders) means pooled effect sizes should be interpreted alongside prediction intervals. Graphical abstract The graphical abstract was created using BioRender. Abu Mhanna, H. (2026) https://BioRender.com/2b8823g .

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