Abstract Introduction Bronchiolitis Obliterans Organizing Pneumonitis (BOOP) is a rare inflammatory lung condition characterized by granulation tissue obstructing bronchioles and alveolar ducts. While often responsive to corticosteroids, recurrence and progression can occur. This report compares two BOOP cases focusing on diagnostic approach and treatment outcomes. Combined Case Summary Table Discussion•Diagnostic Similarity: Both cases required CT-guided biopsy for confirmation after initial imaging and bronchoscopy were inconclusive.•Treatment Strategy: Case 1 involved prolonged corticosteroid therapy with immunosuppressant addition, while Case 2 responded rapidly to high-dose steroids and adjunct antibiotic therapy due positive culture of MSSA.•Outcome: Case 1 had recurrence at one year, highlighting the need for long-term monitoring. Case 2 showed rapid improvement and shorter treatment duration. Conclusion BOOP management varies significantly based on severity and response to therapy. In both cases, a CT guided biopsy was essential for diagnosis. It is crucial to continue investigation when bronchoscopy does not provide results. Early aggressive corticosteroid therapy may lead to faster resolution, while older patients may require prolonged immunosuppression and careful tapering. This abstract is funded by: None
Englutt et al. (Fri,) studied this question.