The COPD Diagnostic Questionnaire (CDQ) demonstrated good discriminatory ability for detecting COPD (AUC 0.8309), with a cutoff >19.5 yielding 73.01% diagnostic accuracy compared to spirometry.
Cross-Sectional (n=126)
No
Does the COPD Diagnostic Questionnaire (CDQ) accurately detect COPD in at-risk Filipino patients compared to spirometry?
The COPD Diagnostic Questionnaire (CDQ) demonstrates acceptable discriminative ability and high negative predictive value, making it a viable screening tool for COPD in low-resource settings prior to spirometry.
Effect estimate: AUC 0.8309
Abstract Rationale In the Philippines, COPD is the seventh leading cause of death and has a significant impact on patients’ quality of life. Fortes et al in 2023, identified 59.3% of COPD were underdiagnosed in the Philippines, highlighting the need for bridging the gaps for awareness and access to healthcare. Pre-selection of patients with symptoms or relevant risk factors using the COPD Diagnostic Questionnaire (CDQ) may aid in a more economical utilization of spirometry. This study aims to determine the validity of CDQ in terms of accuracy as a diagnostic tool for detection of COPD among at risk patients, using spirometry as gold standard. Methods Prospective cross-sectional study of patients in St. Luke’s Medical Center - Quezon City outpatient department, private patients, patients from the barangay health centers of District 4 Quezon City assessed by to have risk factors of COPD between May 2024 to March 2025. Results A total of 126 patients were included in the study. A higher proportion of patients with COPD reported presence of cough even without cold: 55.6% of COPD patients reported a cough even without a cold, compared to only 24.2% in non-COPD patients (p = 0.002), presence of early morning cough: 66.7% of COPD patients experienced early morning cough, while only 44.4% of non-COPD patients did (p = 0.041) and wheezing: 40.7% of COPD patients reported wheezing, compared to 19.2% in those without COPD (p = 0.020), indicating a distinct clinical profile. The AUC of CDQ as a continuous data is 0.8309, indicating that it has good discriminatory ability. The diagnostic accuracy of CDQ 19.5 at 73.01% is higher compared to 58.73% for CDQ 16.5, suggesting that using the higher cut off point will provide better accuracy in diagnosing COPD. Both cutoff CDQ 16.5 and CDQ 19.5, has high NPVs at 96.08% and 92.21% respectively. CDQ of 19.5 with an LR+ of 2.75 is better for ruling in COPD, while CDQ 16.5 is more helpful in ruling out COPD. Overall, CDQ at both cutoff points showed acceptable discriminative ability, sensitivity and NPV in diagnosing COPD. Conclusion CDQ showed acceptable result as a screening tool however, reliance solely on the questionnaire may overlook cases of COPD. In low resource areas where access to spirometry is limited, CDQ may be an alternative diagnostic test to screen high risk patients, promoting early diagnosis and treatment. Spirometry however remains the gold standard diagnostic test used to detect COPD. This abstract is funded by: None
Cruz et al. (Fri,) conducted a cross-sectional in Chronic Obstructive Pulmonary Disease (COPD) (n=126). COPD Diagnostic Questionnaire (CDQ) vs. Spirometry was evaluated on Validity of CDQ in terms of accuracy as a diagnostic tool for detection of COPD (AUC 0.8309). The COPD Diagnostic Questionnaire (CDQ) demonstrated good discriminatory ability for detecting COPD (AUC 0.8309), with a cutoff >19.5 yielding 73.01% diagnostic accuracy compared to spirometry.