B25-03 Temporal Trends and Disparities in Acute Myocardial Infarction-Associated Mortality Among U.S. Cancer Patients Aged ≥55 Years. A CDC Wonder Analysis, (1999-2024)

Abstract Introduction Acute myocardial infarction (MI) remains a critical contributor to mortality among U.S. cancer patients. Cancer-related inflammation and vascular compromise may elevate MI risk and severity. Recent data reveal significant declines in MI-associated mortality over time, yet persistent disparities remain across demographic and geographic factors. Methods The mortality data from the CDC WONDER multiple cause of death for adults aged ≥55 years were used retrospectively to analyze age-adjusted and crude mortality rates (AAMRs and CMRs) per 100,000 for MI (ICD-10 Codes: I21.0-I21.9) and cancer (ICD-10 Codes: C00-D48), stratified by year, gender, race/ethnicity, and geography. Joinpoint regression was used to estimate average annual percent change (AAPC) and annual percent change (APC) with 95% confidence intervals (CIs). Statistical significance was defined as p 0.05. Results From 1999 to 2024, 247,300 deaths were reported from acute MI in cancer patients aged ≥55 years, predominantly in medical facilities. The overall AAMR has dropped significantly from 21.25 in 1999 to 9.17 in 2024 (AAPC: -3.37; 95%CI: -4.07 to -2.65; p 0.001) with a particularly notable decline between 2002 and 2014 (APC: 5.35; p 0.001). Although the overall trend was declining, a non-significant rise occurred between 2018 and 2021. Adults aged ≥85 experienced the highest mortality among all age groups (CMR: 45.18). Both male and female patients exhibited a decrease in AAMRs, with men showing nearly double the rate compared to women (19.84 vs. 8.69). By race, AAMRs were greatest in Non-Hispanic (NH) Blacks (15.91), and lowest in NH Asian or Pacific Islanders (8.09). Rural areas (16.87) exceeded urban areas (12.51). Regionally, the Midwest recorded the peak AAMR at 13.75. At the state level, Arkansas, Mississippi, and Rhode Island ranked highest in the top 90th percentile. Conclusion Despite a significant decline in MI-related mortality among cancer patients aged ≥55 years, disparities persist, especially among older adults, men, NH Black individuals, and those in rural and Midwestern regions. Targeted prevention strategies and equitable access to cardiovascular care are needed to further reduce mortality and address persistent health inequities in vulnerable populations. This abstract is funded by: None