The present study was undertaken to investigate the hepatoprotective activity of Terminalia belerica fruits extract (400 mg/kg p.o.) Gallic Acid (200 mg/kg p.o.) supplemented with an antioxidant lipoic acid (100 mg/kg p.o.) on sub-chronic exposure of carbon tetrachloride (0.15 ml/kg i.p. for 21 days) induced toxicity. Liver damage by carbon tetrachloride was evident by the increase in the level of hepatic marker enzymes such as transaminases, serum alkaline phosphatase and lactate dehydrogenase. Toxicant exposure caused significant increase in blood sugar level where as significant fall was found in glycogen contents (P¬<0.01). Significant elevation was observed in hepatic lipid peroxidation on the contrary a considerable fall was found in reduced glutathione after CCl4 administration. Co-administration of active principle and lipoic acid completely ameliorated the CCl4 induced oxidative damage. Combination of active principle and lipoic acid significantly (P<0.01) ameliorated the liver function test and markers of oxidative stress. Thus it may be concluded that combination therapy was effective against subchronic toxicity of carbon tetrachloride.
Anjana Jadon (Sun,) studied this question.
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