BACKGROUND: Mental disorders are highly prevalent and frequently comorbid, contributing to substantial functional impairment and reduced quality of life. The Hierarchical Taxonomy of Psychopathology provides a dimensional, empirically derived framework that organizes psychopathology hierarchically, addressing limitations of traditional categorical nosologies. AIMS: Examine (1) the latent structure of HiTOP using dimensional measures aligned with the model, and (2) associations between hierarchical dimensions and functional outcomes, including global functioning and personality functioning. METHODS: = 343) samples completed measures assessing internalizing, externalizing, detachment, and thought disorder domains, as well as functional impairment (WHODAS 2.0) and personality functioning (LPFS-BF 2.0). RESULTS: -factor showing the strongest correlations with functional and personality impairment. Self-functioning was more closely linked to internalizing and detachment dimensions, whereas interpersonal functioning related primarily to externalizing processes. CONCLUSIONS: These findings provide empirical support for HiTOP's hierarchical structure and highlight its clinical utility for predicting real-world functional outcomes, underscoring the importance of transdiagnostic, dimensional approaches in assessment and intervention.
Sánchez-García et al. (Wed,) studied this question.