Introduction: Doshas are considered as the fundamental factors responsible for both physiological balance and disease manifestation. Any deviation from their normal state (Dosha Vaishamya) leads to pathological conditions. Objective: To analyse the concept of Dosha Vaishamya, its stages of progression (Kriya Kaala), types of vitiation and the role of causative factors (Nidana) in disease manifestation. Materials and Methods: A comprehensive literary review was conducted using classical Ayurvedic texts, modern textbooks and scholarly articles to analyse the stages, causes and manifestations of Dosha Dushti. Result and Discussion: Dosha Vaishamya primarily manifests as Vrudhi (increase) and Kshaya (decrease) along with other pathological states such as Utklesha, Sthambhana, Leena and plenty more. Disease progression occurs through six stages of Kriya Kaala-Sanchaya, Prakopa, Prasara, Sthana Samshraya, Vyakti and Bheda. Nidana plays a critical role in initiating Dosha vitiation, while factors like Kha Vaigunya and Ashraya–Ashrayi Bhava determine localization. Vata Dosha governs the movement (Gati) of vitiated Doshas, influencing disease spread and site of manifestation. The interaction between Dosha and Dushya leads to disease manifestation, while latent stage (Leena), obstructed (Sthambhana) etc highlight the dynamic nature of Dosha imbalance. Understanding Nidana, Dosha Gati and Samprapti Ghatakas aid in accurate diagnosis and planning of treatment. Conclusion: Dosha Vaishamya is the key point in pathogenesis of any diseases. A thorough understanding of its stages, causative factors and dynamics is essential for effective disease management, prevention and restoration of health.
Devi S Nair (Wed,) studied this question.
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