Beta-lapachone inhibits migration and epithelial–mesenchymal transition in highly metastatic and invasive 4T1 murine mammary tumor spheroids

Key Points

• The study aims to explore the effects of beta-lapachone on inhibiting migration and epithelial–mesenchymal transition in 4T1 murine mammary tumors.
• Examination of 4T1 murine mammary tumor spheroids
• Assessment of migration and epithelial-mesenchymal transition
• Analysis of effects of beta-lapachone administration
• Beta-lapachone significantly reduced migration of 4T1 tumor spheroids
• Epithelial-mesenchymal transition markers were downregulated
• Inhibition of metastasis was observed in vivo with beta-lapachone treatment

Abstract