Glaucoma is a complex condition with an unknown exact cause, but it involves progressive damage to the optic nerve. This damage is primarily driven by high eye pressure, poor blood flow, and oxidative stress, a process linked to cell ageing and inflammation that harms the retina. Recent research highlights that these issues stem from structural changes in the eye’s drainage system and visual pathways, which can be analysed through the lens of engineering thermodynamics. This study proposes a thermal explanation for the physiological processes linking ocular behaviour to inflammatory ion flux alterations. We develop a thermal model demonstrating that temperature increases are tied to the mechanical work necessary for maintaining water flux in the anterior ocular chamber. We show that these changes alter the membrane potential and tissue pH, resulting in elevated intraocular pressure. By clarifying the temperature–pressure effect, this research establishes a theoretical framework to study the developments of future glaucoma therapies.
Grisolia et al. (Fri,) studied this question.