The Application of Nalbuphine Pretreatment in Patients Undergoing Laparoscopic Surgery for Uterine Fibroids

Key Points

• To analyze the effects of nalbuphine pretreatment on perioperative stress responses and Ramsay Sedation Scale scores in patients undergoing laparoscopic surgery for uterine fibroids.
• Prospective study involving 90 patients at Liaocheng Second People's Hospital from January to December 2024, divided into control and study groups.
• Control group received standard anesthesia, while the study group received nalbuphine pretreatment alongside general anesthesia.
• Comparisons were made on stress responses and RSS scores between the two anesthesia methods.
• No significant difference in operation time and intraoperative blood loss between groups (P>0.05).
• At surgery completion and 6 hours post-operation, cortisol and adrenaline levels were higher than pre-anesthesia in both groups, but the study group had significantly lower stress markers (P<0.05).
• Pain scores and RSS scores were higher at 3 hours post-operation compared to 1 hour, with the study group showing significantly lower scores at both time points (P<0.05). Adverse event rates were lower in the study group with statistical significance (P<0.05).