Male sex (OR 5.187), higher TyG index (OR 1.811), and lower PNI (OR 0.544) were independent predictors of coronary slow flow phenomenon in patients under 65 years undergoing coronary angiography.
Observational (n=214)
No
Are metabolic and immunonutritional indices associated with coronary slow flow phenomenon in non-elderly patients undergoing coronary angiography?
In non-elderly patients undergoing coronary angiography, male sex, higher TyG index, and lower PNI are independently associated with the presence of coronary slow flow phenomenon.
Effect estimate: OR 1.811 (95% CI 1.251-2.622)
p-value: p=0.002
Background/Objectives: Coronary slow flow phenomenon (CSFP) is considered a condition identified during coronary angiography (CAG), associated with recurrent ischemic symptoms and adverse cardiovascular outcomes while no significant epicardial coronary obstruction is present. The combined predictive role of metabolic and nutritional indices in CSFP has not been fully elucidated. Methods: This analysis, based on a retrospective observational design at a single center, included 214 patients aged < 65 years undergoing CAG who had either normal coronary arteries (NCA) (n = 100) or CSFP (n = 114). CSFP was defined using the TIMI frame count criteria. The triglyceride-glucose (TyG) index, Prognostic Nutritional Index (PNI), Controlling Nutritional Status (CONUT) score, Naples prognostic score (NPS), and C-reactive protein–albumin–lymphocyte (CALLY) index were calculated. Logistic regression was employed to assess independent contributors to CSFP. Results: In comparison with the NCA group, patients with CSFP were more frequently male (73.7% vs. 43.0%, p < 0.001) and active smokers (33.3% vs. 19.0%, p = 0.018). Among these calculated indices, higher TyG index values were observed; in contrast, the CSFP group exhibited lower PNI and CALLY index values. In multivariable analysis, male sex (OR = 5.187, 95% CI: 2.520–10.674, p < 0.001), the TyG index (OR = 1.811, 95% confidence interval CI: 1.251–2.622, p = 0.002), and PNI (OR = 0.544, 95% CI: 0.362–0.817, p = 0.003) retained their predictive value for CSFP. Conclusions: Coronary slow flow phenomenon in a non-elderly cohort appears to be linked to metabolic dysfunction, immunonutritional imbalance, and sex-specific differences, with the combined evaluation of the TyG index, PNI, and male sex potentially enhancing risk stratification.
Kaynak et al. (Fri,) conducted a observational in Coronary slow flow phenomenon (n=214). Metabolic and nutritional indices (TyG index, PNI) vs. Normal coronary arteries was evaluated on Presence of coronary slow flow phenomenon (OR 1.811, 95% CI 1.251-2.622, p=0.002). Male sex (OR 5.187), higher TyG index (OR 1.811), and lower PNI (OR 0.544) were independent predictors of coronary slow flow phenomenon in patients under 65 years undergoing coronary angiography.