Background: Alzheimer's disease (AD) is a neurodegenerative disorder that accounts for more than half of all dementia cases and is a major cause of death worldwide, especially among the aging population. The brain experiences oxidative stress due to an increase in reactive oxygen species (ROS) combined with a decline in cellular antioxidant defences. Elevated ROS levels can harm cel-lular structures and molecules, leading to oxidation of proteins, lipids, DNA, and RNA, which con-tributes to the build-up of amyloid-β plaques and neurofibrillary tangles composed of hyperphosphor-ylated tau. In the brain, free radicals can accumulate due to various factors such as aging, inflamma-tion, and mitochondrial dysfunction. Methods: In this review, we aim to explore the role of free radicals in the progression of AD and to furnish insights into various antioxidants that have been shown to be beneficial in combination with conventional therapy. Results: The findings of various epidemiological and clinical studies demonstrate the synergistic role of antioxidants with established medication in reducing progression and symptoms of AD. They re-duce the neuroinflammation and oxidative stress caused by various free radicals in the brain. Conclusion: The review aims to outline the fundamentals of AD and the importance of antioxidants in its management. It also seeks to assist researchers in developing more effective antioxidant-based therapeutic strategies for AD, incorporating insights from relevant clinical trials in the field.
Ansari et al. (Wed,) studied this question.