A novel myocarditis prognostic score ≥ 5 identified cardiovascular outcomes with 100% sensitivity, 87% specificity, and an AUC of 1.
Cohort (n=98)
Can a multiparametric myocarditis prognostic score identify patients at higher risk of cardiovascular outcomes?
A newly developed multiparametric myocarditis prognostic score accurately identifies patients at high risk of cardiovascular outcomes, with a score ≥ 5 showing 100% sensitivity and 87% specificity.
Background: Myocarditis is an inflammatory disease of the myocardium with multiple causes and evolutions. The aim of our study was to design a prognostic multiparametric score in patients with myocarditis, to identify those at higher risk of cardiovascular outcomes. Methods: A prospective study was performed enrolling 98 patients with myocarditis: 72 M, 26 F; median age 27 IQR 20–40. Patients were divided into two groups: complicated (CM) and uncomplicated myocarditis (UM). Six months after hospital admission, cardiac magnetic resonance (CMR) and cardiological consultation were repeated. Cardiovascular outcomes (death, hospitalization for heart failure, heart transplant, ICD implantation, and heart failure development) were evaluated at 6 months and after 3 years. Results: We found 67 UM and 31 CM. Cardiovascular outcomes were significantly higher in patients with CM. We found a significant correlation between cardiovascular outcomes and reduced LVEF at hospital admission, reduced global longitudinal strain in absolute values, septal late gadolinium enhancement (LGE) at CMR, longer persistence time of increased troponin, LGE extension progression or persistence at 6 months of CMR. A myocarditis prognostic score was developed. A score ≥ 5 showed higher sensitivity (100%) and specificity (87%)—AUC 1, to identify cardiovascular outcomes in patients with myocarditis. A score between 3 and 4 showed high sensitivity but low specificity. A score ≤ 2 was associated with low probability of cardiovascular outcomes. Conclusion: Our study confirms the high probability of cardiovascular outcomes in patients with CM and it suggests a myocarditis prognostic score to identify patients at higher risk of cardiovascular outcomes.
Lisi et al. (Sat,) conducted a cohort in Myocarditis (n=98). Myocarditis prognostic score was evaluated on Cardiovascular outcomes (death, hospitalization for heart failure, heart transplant, ICD implantation, and heart failure development). A novel myocarditis prognostic score ≥ 5 identified cardiovascular outcomes with 100% sensitivity, 87% specificity, and an AUC of 1.