Scaling up YFV 17DD virus to a 40-liter pilot-scale stirred-tank bioreactor at Bio-Manguinhos Pilot Plant

Key Points

• The goal is to explore the production efficiency of YFV 17DD virus in a larger bioreactor setting.
• Utilized a 40-liter stirred-tank bioreactor for scaling up the virus production.
• Conducted within the Bio-Manguinhos Pilot Plant facilities.
• Presented at the International Symposium on Immunobiologicals.
• Successful implementation of the bioreactor scale-up process.
• Potential improvements in the yield and efficiency of YFV 17DD virus production.
• Highlights the advancements in biomanufacturing for vaccine development.