What question did this study set out to answer?

This research focuses on evaluating the rates at which high-risk patients fail to meet LDL-C management goals as per the 2022 JAS guidelines.

May 29, 2026Open Access

Non-Achievement of Low-Density Lipoprotein Cholesterol Management Goals　― Implications on High-Risk Cardiovascular Disease Patients Within the Japan Atherosclerosis Society 2022 Guideline Recommendations ―

Key Points

This research focuses on evaluating the rates at which high-risk patients fail to meet LDL-C management goals as per the 2022 JAS guidelines.
Utilized a nationwide real-world dataset of ASCVD patients.
Evaluated non-achievement rates of LDL-C goals across different risk groups.
Followed the JAS guidelines for LDL-C target recommendations.
Identified significant non-achievement rates of LDL-C management goals across various risk groups.
Non-achievement of LDL-C goals correlates with increased cardiovascular risk.
Implications suggest potential areas for improvement in patient management and adherence to guidelines.

Abstract

Background: Low-density lipoprotein cholesterol (LDL-C) is an established therapeutic target for atherosclerotic cardiovascular diseases (ASCVD), particularly in high-risk individuals. In 2022, the Japan Atherosclerosis Society Guidelines (JAS-GL) for Prevention of Atherosclerotic Cardiovascular Diseases introduced more stringent LDL-C targets to reduce ASCVD. We evaluated the non-achievement rates of the LDL-C goals across risk groups using a nationwide real-world dataset, which included a broad range of ASCVD patients.

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