Impact of lipid composition on the physicochemical properties and in vitro expression of mRNA-loaded lipid nanoparticles

Key Points

• The study aims to evaluate how different lipid compositions influence the properties and mRNA expression of lipid nanoparticles.
• Investigated various lipid compositions
• Analyzed physicochemical properties of lipid nanoparticles
• Assessed in vitro expression of mRNA-loaded nanoparticles
• Different lipid compositions resulted in varied physicochemical properties of nanoparticles.
• Certain lipid mixtures enhanced mRNA expression more effectively than others.