In individuals with normal kidney function, increasing potassium intake reduces blood pressure irrespective of the accompanying anion and with minimal effects on electrolyte and acid-base parameters.1-3 However, the effects of potassium and its accompanying anion in patients with chronic kidney disease (CKD) are unclear and raise concerns regarding hyperkalemia. Our previous analysis showed that 40 mmol/day of potassium chloride supplementation increased plasma potassium by 0.4 mmol/L and caused mild metabolic acidosis, which could counteract the beneficial effects of potassium.
Wieërs et al. (Fri,) studied this question.