Markers of Increased Risk of death in Poly Trauma Patients in Conformity with Trauma Scores

Background: A high-risk patient with many injuries can be located using the Berlin polytrauma definition. This definition encompasses injuries where there is at least one physiological risk factor and an abbreviated injury scale score of 3 or higher in at least two areas of the body. Are based on age, particular threshold values for the Glasgow coma scale (GCS), acidosis, coagulopathy, and hypotension.Aim and objectives: To identify polytrauma patients, measure blood biomarkers (CPK, troponin I, Lactate, and alkaline phosphatase), and compare these biomarkers to trauma scores in order to establish early mortality predictors in polytrauma patients.Patients and methods: Observational prospective study for 40 patients coming to Al-Azhar University hospitals (El-Hussin-Sayed Galal) recruited from the Emergency &Critical Care Department. The duration of the recruiting period was 6 months, starting from May 2023 till the end of October 2023.Results: GCS can significantly predict mortality in polytrauma patients (P<0.001 and Area under the curve (AUC)=0.955) at cut-off ≤7 with 77.78% sensitivity, 90.32% specificity, 70% positive predictive value (PPV), and 93.3% negative predictive value (NPV). Revised Trauma score (RTS) can significantly predict mortality in polytrauma patients (P=0.002 and AUC=0.823) at cut-off≤4 with 77.78% sensitivity, 74.19% specificity, 46.7% PPV and 92% NPV.Conclusion: Mortality rate in polytrauma patients is associated with lower GCS and revised trauma score (RTS)and higher CPK, Lactate, and injury severity score (ISS). There was a negative correlation between GCS and (creatine phosphokinase (CPK) and Lactate). A negative correlation between RTS and (CPK and Lactate) and a positive correlation between ISS and (CPK and Lactate).