A case of locally advanced unresectable pancreatic cancer with pathologic complete response after conversion surgery

Key Points

• The aim is to evaluate the efficacy of preoperative chemotherapy followed by conversion surgery in locally advanced unresectable pancreatic cancer.
• Administered one cycle of gemcitabine plus nab-paclitaxel therapy and four cycles of modified FOLFIRINOX.
• Performed conversion surgery after tumor shrinkage and normalization of tumor markers after seven months of chemotherapy.
• Conducted a post-operative pathology examination to assess tumor response.
• Achieved pathologic complete response with no residual tumor cells detected in the pathology samples.
• Underwent conversion surgery successfully with visible tumor shrinkage around the mesenteric vessels.
• Patient is currently 29 months disease-free after surgery, following six months of adjuvant S-1 monotherapy.