Background Between 2023 and 2025, dentistry underwent a wave of validated technological and systemic changes. FDA-cleared artificial intelligence (AI), robotic/guided surgery, direct 3D printing, and HL7® FHIR® interoperability standards shifted dentistry from isolated innovation toward integrated digital infrastructure. However, cultural, educational, and economic barriers limit digital adoption. Understanding how market-ready innovations interact with opportunities and barriers is essential to guide dentistry’s trajectory toward 2035.Methods An integrative review synthesized data from regulatory listings, industry communications, peer-reviewed literature, standards (ADA, ANSI/ADA, HL7), policy reports, patient surveys, and workforce studies (2019-2025). Findings were organized into eight domains and interpreted across diverse health-system contexts to enhance global applicability.Results Market-ready technologies, e.g. AI diagnostics, robotic/navigated surgery, chairside manufacturing, interoperability standards, and teledentistry, are increasingly validated and available. Adoption remains uneven due to reimbursement misalignments, capital requirements, cultural legacies, variable faculty readiness, and inequitable digital access. Patients expect digital convenience and transparency, often outpacing practice transformation. DSO and non-traditional entrants reshape delivery models. These dynamics collectively signal a transition from episodic, restorative care toward a preventive, digital, and interdisciplinary paradigm.Conclusions Dentistry is at a digital inflection point where technological capability exceeds system readiness. The trajectory toward 2035 will depend on alignment across policy, education, and professional culture to position as an integrated, regenerative, patient-centered component of global health and mitigate risks of technological fragmentation and widening inequity. Strategic investments in workforce training, interoperable infrastructure, and reimbursement reform are essential to enable equitable adoption and realize the potential benefits of digitally integrated oral healthcare.
Adkins et al. (Wed,) studied this question.