Structured Abstract Background The IRM Impossibility Theorem (companion Article 1) establishes that zero-drift self-maintenance is mathematically impossible in any self-referentially self-maintaining (SRSM) system without external reference. This impossibility result has a constructive engineering corollary: the unique escape from IRM drift is external reference, and the theorem specifies the minimum amount of external reference required. Gap No unified engineering framework has derived the minimum external intervention frequency for SRSM systems across multiple domains from a single mathematical principle. Domain-specific intervention protocols (reprogramming schedules, circuit-breaker calibration, oversight frequency, input diversity protocols, TMS schedules) have been designed empirically or by analogy, without a common derivation. Approach We derive domain-specific applications of the master formula fₘin = η/ (ε*·R) for five confirmed IGT systems: biological ageing, market microstructure, AI value alignment, phonological acquisition, and neural consciousness in disorders of consciousness (DOC) patients. For each domain we specify η (intrinsic noise rate), ε* (functional tolerance threshold), and R (maintenance redundancy), and derive the minimum intervention protocol. Results Five novel intervention protocols derived from a single formula: (1) intermittent partial reprogramming at 1 session per 12–24 months for post-mitotic ageing tissue; (2) dynamic spectral-gap-triggered circuit breakers outperforming fixed price-movement triggers; (3) first formally derived oversight schedule for AI alignment; (4) minimum phonological input diversity protocol for multilingual acquisition; (5) individually calibrated TMS frequency for DOC consciousness maintenance. Implications All five protocols are jointly derived from the same mathematical principle, jointly novel relative to existing protocols, and jointly testable. The framework establishes that optimal intervention design for SRSM systems requires measuring three domain-specific parameters (η, ε*, R) and applying a single cross-domain formula. Keywords: external reference, IRM theorem, fₘin formula, SRSM stabilisation, ageing reprogramming, market circuit breaker, AI oversight, phonological input diversity, TMS protocol, DOC, ALGUILAS-AI
José Caetano de Mattos (Wed,) studied this question.