Cervical cancer age-adjusted mortality rates in US females aged ≥25 years significantly declined from 4.90 per 100,000 in 1999 to 3.85 in 2020 (AAPC -1.34; 95% CI -1.47 to -1.19).
Observational (n=99,994)
Yes
Cervical cancer-related mortality in the US significantly declined from 1999 to 2020, though disparities persist across racial, regional, and urban/rural lines.
Effect estimate: AAPC -1.34 (95% CI -1.47 to -1.19)
Absolute Event Rate: 3.85% vs 4.9%
e17517 Background: Cervical cancer is a malignant epithelial tumor that forms in the cervix of the uterus, caused primarily by the persistent infection with sexually transmitted human papillomavirus (HPV). It is the fourth most common malignancy in women with nearly half a million women diagnosed with cervical cancer annually worldwide. We aim to analyze the trends for cervical cancer-related mortality in adult females in the United States stratified by age, race and ethnicity, and region. Methods: Using the CDC WONDER mortality database, we determined age-adjusted mortality rates (AAMRs) and crude death rates (CRs) per 100,000 females aged 25 and above from 1999 to 2020. Changes in CRs and AAMRs were determined through annual percentage changes (APCs) and average annual percentage changes (AAPCs) using Joinpoint regression. Results: From 1999-2020, cervical cancer caused a total of 99,994 deaths in adult females across the US. The overall AAMR declined from 4.90 in 1999 to 3.85 in 2020, demonstrating a significant decreasing trend (AAPC: -1.34, 95% Confidence Interval (CI), -1.47 to -1.19). Non-Hispanic (NH) Black or African American experienced the highest mortality (AAMR: 6.97), followed by Hispanic or Latino (4.61), NH American Indian or Alaska Native (AAMR: 4.55), NH White (3.61), and NH Asian or Pacific Islander (3.14). Despite the highest mortality burden, NH Blacks showed the highest decrease in mortality (AAPC: -2.76, 95% CI: -3.01 to -2.44), and NH Whites showed the lowest (AAPC: -0.89, 95% CI: -1.09 to -0.66). Regionally, the mortality burden was the highest in the South (AAMR: 4.63), followed by the Midwest (3.85), the West (3.7), and the Northeast (3.60). Among the census regions, the Northeast showed the highest decline in mortality (AAPC: -2.41, 95% CI: -2.66 to -1.97), while the Southeast showed the lowest (AAPC: -1.00, 95% CI: -1.26 to -0.7) despite having the highest burden. Non-metropolitan areas (AAMR: 4.72) had higher mortality than metropolitan areas (3.94) and experienced almost half the decline as in the metropolitan areas (AAPCs: -0.76 vs 1.37 respectively). Mississippi (6.21) and Arkansas (5.87) had the highest state AAMRs, while Utah (2.60) and Massachusetts (2.32) had the lowest. Conclusions: Our analysis shows a significant decline in cervical cancer-related mortality among adult females across the US, particularly in NH Black or African American women. However, NH Whites, the Southern region, and the non-metropolitan areas showed the least decline despite having the highest mortality burden. Targeted healthcare policies are needed to address these disparities.
Hafiz Aqib Ilyas (Thu,) conducted a observational in Cervical cancer (n=99,994). Cervical cancer age-adjusted mortality rates in US females aged ≥25 years significantly declined from 4.90 per 100,000 in 1999 to 3.85 in 2020 (AAPC -1.34; 95% CI -1.47 to -1.19).