Novel tripartite CPSF7::RARG::CPSF7 fusion confers primary ATRA resistance in atypical acute promyelocytic leukemia

Key Points

• This research investigates the role of the CPSF7::RARG fusion in mediating resistance to all-trans retinoic acid (ATRA) in leukemia.
• Analyzed the molecular structure of the CPSF7::RARG fusion
• Examined its impact on ATRA response in atypical acute promyelocytic leukemia models
• The CPSF7::RARG fusion leads to significant ATRA resistance, hindering effective treatment.
• Patterns of gene expression suggest alterations in physiological pathways related to retinoic acid signaling.