To Formulate and Evaluate Benzocaine Lozenges for Optimized Local Treatment of Mouth Ulcers With Improved Patient Compliance

Mouth ulcers (aphthous ulcers) are lesions in the oral mucosa, which cause pain and may affect eating, talking, and even affect the quality of life of an individual. Treatment options such as application of topical gels may help alleviate the condition temporarily; however, patient compliance is still affected by the bad taste and difficulty in applying the medication. This study intends to prepare medicated lozenges, which have Benzocaine as active ingredient to manage cases of mouth ulcers. The use of medicated lozenges ensures prolonged retention of the drug in the oral cavity, resulting in sustained release and enhanced effect. Lozenges were formulated using sucrose matrix and excipients appropriate for their purpose. These lozenges were subjected to various evaluations such as weight variation, hardness, and dissolution. Results obtained show that the medicated lozenges have acceptable physicochemical properties and have enhanced patient acceptance because of palatability. Therefore, medicated lozenges can be considered an ideal substitute for conventional gel formulations used for mouth ulcers