Nanocarrier-Enabled Therapies for Psoriasis: AComprehensive Review of Recent Developments

Introduction: Psoriasis is a chronic autoimmune skin disorder marked by excessive keratinocyte proliferation and persistent inflammation. Conventional treatments like topical agents, systemic drugs, etc. offer relief but are limited by poor skin penetration, side effects, and low patient compliance. This outlines the disease pathology and highlights the potential of a nanocarrier-based drug delivery system to overcome these therapeutic challenges. Method: A review of recent literature was conducted using major peer-reviewed databases to identify studies evaluating the role of nanocarriers in psoriasis management. Articles describing the pathophysiology, limitations of conventional therapies, and advancements in nanocarrier-based systems. Result: Findings from the reviewed studies demonstrated that nanocarriers significantly improve drug penetration, retention, and localized delivery to psoriatic skin. Their nanoscale dimensions, high surface area, and superior encapsulation abilities enable controlled and sustained drug release. Most studies reported enhanced therapeutic efficacy, reduced systemic exposure, and minimized therapies. Discussion: The integration of nanotechnology into psoriasis treatment effectively addresses several shortcomings of existing therapies. By enabling site-specific and prolonged drug release, nanocarriers align well with precision medicine approaches and offer improved clinical outcomes. However, challenges persist, including a lack of standardized evaluation protocols, limited clinical translation, and insufficient long-term safety data. Addressing these gaps remains essential for advancing nanocarrierbased therapies towards routine clinical use. Conclusion: Nanocarrier-enabled drug delivery systems represent a promising advancement in psoriasis therapy. Their ability to improve drug bioavailability, therapeutic effectiveness, and patient compliance highlights their potential to transform future dermatological care and reinforces the need for continued research and clinical exploration