An Integrative Approach in the Management of Diabetic Peripheral Neuropathy: A Review.

Diabetic Peripheral Neuropathy (DPN) is a common and debilitating complication of Diabetes Mellitus, characterized by progressive nerve damage leading to pain, numbness, and sensory significantly to morbidity and reduced quality of life. Clinically, DPN presents with diminished vibration perception and impairment of multiple sensory modalities. Chronic hyperglycaemia plays a central role in its pathogenesis through oxidative stress, microvascular damage, and nerve ischemia, ultimately leading to neuronal degeneration and complications such as foot ulceration and gait disturbances. In Ayurveda, the clinical features of DPN can be correlated with Suptata (numbness) and Daha (burning sensation), described under Poorvarupa and Upadrava of Prameha. It can be considered a form of Dhatu Upadhatu Pradoshaja Vatavyadhi, wherein Vata Dosha predominates. The underlying pathogenesis involves Dhatukshaya (tissue depletion) and Margavarana (channel obstruction), with the involvement of Pitta, Kapha, and Meda dushya. Despite advancements in conventional therapy, management remains largely symptomatic with limited success in preventing disease progression. An integrative approach combining modern medicine with Ayurvedic principles may offer a more comprehensive strategy by addressing both symptoms and underlying pathology, thereby improving patient outcomes and quality of life.