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This research investigates the relationship between brain-derived neurotrophic factor and major depression.

June 4, 2026Open Access

Major Depression and Brain-Derived Neurotrophic Factor

RYReiji YOSHIMURAUniversity of Occupational and Environmental Health Japan

Key Points

This research investigates the relationship between brain-derived neurotrophic factor and major depression.
Examined blood levels and genetic polymorphisms of BDNF in relation to depression severity.
Analyzed cerebrospinal fluid concentrations and associated neuroplasticity markers.
Utilized artificial intelligence for data analysis and standardization of measurement methods.
Higher levels of BDNF correlate with reduced depression severity and better treatment response.
Changes in the mBDNF/proBDNF ratio are linked to neuroplasticity and depression outcomes.
The Val66Met polymorphism significantly influences individual treatment responsiveness.

Abstract

Depression is a mental disorder characterized by biological and psychosocial diversity, hindering the identification of effective diagnostic biomarkers. Brain-derived neurotrophic factor (BDNF), a neurotrophic factor, has garnered attention recently, with its blood levels, genetic polymorphisms, and cerebrospinal fluid concentrations correlating with depression severity and treatment response. In particular, changes in the mBDNF/proBDNF ratio, p75NTR, and tropomyosin receptor kinase B concentrations have been suggested to be associated with neuroplasticity. The Val66Met polymorphism and epigenetic changes in the BDNF gene may also influence treatment responsiveness. Standardization of measurement methods, artificial intelligence analysis, and multifactorial integration are expected to facilitate the application of personalized medicine for depression treatment in the future.

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