Women with PCOS had significantly lower serum levels of Angiotensin (1-7) (18.1 vs 21.2 pg/mL) compared to healthy controls, indicating alterations in the renin-angiotensin system.
Case-Control (n=90)
No
Women with PCOS exhibit alterations in the renin-angiotensin system, specifically lower Ang (1-7) levels, and elevated inflammatory markers, though the latter may be driven by BMI.
Absolute Event Rate: 18.1% vs 21.2%
p-value: p=<0.01
Background however, after BMI adjustment, IL-6 became borderline and TNF-α lost statistical significance. Correlation analysis revealed LH and FSH were moderately correlated with TNF-α (r=0.479 and r=0.464, respectively; both P=0.001). ROC analysis identified AMH as the strongest discriminator for PCOS (AUC=0.866), followed by total testosterone (AUC=0.765), while Angiotensin (1-7) showed moderate diagnostic accuracy with an inverse relationship (AUC=0.718). Conclusion: This study identified alterations RAS in women with PCOS, evidenced by lower Ang (1-7) levels, along with associations between inflammatory markers and reproductive hormones. Further prospective studies are required to confirm these findings.
Ahmed et al. (Sat,) conducted a case-control in Polycystic Ovary Syndrome (n=90). Polycystic Ovary Syndrome vs. Healthy controls was evaluated on Serum Angiotensin (1-7) levels (pg/mL) (p=<0.01). Women with PCOS had significantly lower serum levels of Angiotensin (1-7) (18.1 vs 21.2 pg/mL) compared to healthy controls, indicating alterations in the renin-angiotensin system.